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pentobarbital will minimize the extent or impact of doxorubicin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pentobarbital will decrease the level or impact of tramadol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Lessened AUC of tramadol plus the active metabolite (O-desme